Little one: Welcome to my Mommy’s podcast.
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Katie: Hiya and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the top. And I’m right here at present with my pal, Naveen, who’s an intensely curious entrepreneur who has been taking up some huge, audacious concepts to push humanity ahead. He’s the creator of the award-winning ebook “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness optionally available by predicting and stopping continual illness by a deeper understanding of a person’s biology at a molecular degree. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse continual illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the 12 months, Most Inventive Particular person by Quick Firm, Prime 20 Entrepreneurs, and lots of extra.
On this episode, we speak in regards to the human ecosystem and customized optimization of your intestine well being and your total well being. We speak in regards to the cause the intestine impacts your complete physique. Why it’s not simply genetics from our mother and father however truly our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at beginning and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals will be good for some individuals and never others, and easy methods to know which is greatest for you, but additionally, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The actual cause it’s necessary to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, plenty of hyperlinks to be taught extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.
Naveen: Nicely, Katie, so good to see you lastly after an extended, very long time.
Katie: I’m so excited we get to have a dialog and get to report it and share it at present, and we’re gonna speak lots about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I’d say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I’d love so that you can simply discuss this as a result of I feel you’re my solely hobbyist Moon rock collector.
Naveen: Nicely, I feel, Katie, you already know, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a approach of expressing that there’s nothing that’s unimaginable for us to do. Regardless that it’s referred to as “Moonshots” that folks thought was tough, if not unimaginable to do and having, you already know, now to have the ability to go to the Moon and to me, the gathering of house rocks truly was simply merely a interest of capable of maintain one thing in your hand. That could be even earlier than the beginning of our planet. And it provides you some concept of how fragile we’re that if we don’t deal with ourselves, our planet, we as humanity could not survive. As a species, we could not survive.
So, you already know, concept of when somebody says, “I’m actually nervous about our planet,” ask the planet and planet will inform you, “Don’t you are worried about me as a result of we…” Planet will just do nice however human species could not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are related collectively. When one thing exterior us goes flawed, we as inner ecosystem may even be impacted, proper. And that’s coming right down to, you already know, if you happen to take a look at what’s above, so under is de facto what’s exterior the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I really like that you simply stated it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you already know him as effectively. And I requested him that query. , your era’s gonna face lots within the environmental and local weather stuff. And, I raised this query and he goes, “Nicely, mother, you’re truly asking the flawed query as a result of the…”
Naveen: Oh, I adore it, I adore it.
Katie: He stated, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we must be asking how we will be extra synergistic inside an atmosphere that’s larger than us.”
Naveen: That’s the excellent reply. That’s precisely how I’d see it that…you already know, when individuals say, “Aren’t you nervous in regards to the planet?” I say, “That’s not the query try to be asking.” It’s, “Are we nervous in regards to the human species?” That’s what we needs to be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I’d say not nervous about however working to unravel. My listeners are fairly well being savvy and perceive or no less than have a passing understanding that intestine well being impacts the entire total physique. However I really feel like this idea is…effectively, we’ve recognized features of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of corporations like Viome, we have now many extra tangible instruments to really perceive and begin to do one thing about that. However to start out broad, type of give us an outline of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, effectively, to start with, you already know, let’s simply begin from the start. We as human beings usually are not merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be truly expressed in our human physique usually are not our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such by way of all of the genes which can be expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re residing of their world. They don’t reside in our world, proper.
So, after we perceive that, you already know, regardless that you may argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you may argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and comfy place to remain. In flip, they feed us the vitamins that our physique wants to really be wholesome, proper. So, think about from the time a child is born, and I feel that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Which means it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by the beginning canal, that is the primary publicity the child will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by beginning canal. And sadly, among the moms for apparent causes find yourself getting a C-section. They really…the infants usually are not going by the identical…they’re uncovered to pores and skin microbiome quite by the beginning canal, the microbiome that they’d get by the beginning canal. And that could be a essentially…the child, when it’s born, is definitely…the character has created in a approach that the microbes get launched into the child on the time of the beginning and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I feel that is the basic half that folks want to know. Seventy % of our immune system is alongside our intestine lining. In truth, all of the analysis exhibits that how intestine microbiome is consistently coaching our immune system what’s a pal and what’s a foe, proper. So, in some sense, if you happen to take a look at the human physique, there’s a tube that goes by us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definately begin to take a look at all alongside the traces there’s a huge quantity of microbial existence there. They usually actually are continually interacting with our immune system and the immune system is now understanding when there’s truly a pathogen that’s coming by the meals or the pathogen that’s coming by the surface world, easy methods to react to it. And these microbes are the primary sign that tells the immune techniques, “This isn’t good. Go do one thing about it, proper.”
And I feel to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I feel as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we lower our pores and skin or whether or not there’s some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are continually in sync and wholesome and our immune system is wholesome, then our physique will truly heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique is just not comfortable, you get illness which we name illness.
Katie: Yeah, so many necessary factors you simply stated to unpack. And I feel the primary being that we actually are extra bacterial than human and also you…right here you stated you’re what you eat however it goes to this point past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you simply introduced up the beginning canal factor as a result of I’m a doula and I’ve truly helped in a number of C-section births with feeding the child, as a result of such as you stated, if you happen to don’t…the child is of course meant to seed their intestine by the beginning canal. And if that doesn’t occur, such as you stated, they’re seeding to the hospital room, to pores and skin, to doubtlessly disinfectants which can be in that room, every kind of issues. And we all know that this intestine micro organism at beginning, increasingly more we be taught, units you up in your complete life. But in addition, the excellent news is…and I do know that Viome does a whole lot of analysis on this. All is just not misplaced if you happen to don’t get an ideal begin. We now have the flexibility to type of get a snapshot and look within the intestine in a very distinctive approach after which optimize to enhance somebody’s well being going ahead.
And in addition, such as you stated, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal approach and simply take away the issues which can be holding the physique from being wholesome or perhaps generally give it little further vitamins to assist get there. Discuss a bit of bit in regards to the science of Viome and what we’re testing as a result of this know-how didn’t even exist a pair many years in the past, and now we have now such superb information from this.
Naveen: Nicely, it’s very fascinating is this concept of, you already know…if you happen to return and take a look at couple of many years in the past, it was truly the micro organism and all these organisms have been thought-about as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as doable as a result of they will’t presumably be there for our good, proper. And as we began to be taught extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re imagined to be there they usually actually…after we feed them issues like, you already know…in olden days, after we have been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s filled with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, truly flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.
In truth, if you happen to begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, if you happen to actually take into consideration all of the issues which can be being executed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it truly impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, you already know, you may name them any names you need, you already know, lots of these items together with autism is now related instantly into the intestine microbiome. In truth, they’ve executed now the analysis the place they did merely a microbial transplant referred to as a fecal transplant they usually have been capable of actually present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been capable of present once you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve executed them in mice they usually’ve executed that actually in people, and clearly, it was executed by mistake however that’s truly the way it occurred.
In truth, what’s actually fascinating is habit. They usually’ve proven the identical factor. They took…there have been 17 individuals on the analysis that have been utterly hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who truly had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind by way of what to do. That’s what the habit is, proper. And I feel that’s actually phenomenal.
And now what we’re studying is each kind of most cancers…actually what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide until it’s there to idiot our immune system into considering that is self and protects the tumor towards the immune system attacking, proper?
Now, think about what…one other factor that’s most fascinating I discovered was once you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the those that immunotherapy didn’t work, they merely have been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome is just not solely there to maintain us wholesome from all of the illnesses at present we name the totally different names. Coronary heart illnesses, it’s coming from our intestine microbes truly producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In truth, we are able to now take a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites truly change the LDL manufacturing. You’re in a position to take a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m making an attempt to make is that you simply talked about one thing about these micro organism, and I simply need individuals to know the microorganisms usually are not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mould. All of these items are literally the entire ecosystem and the most important half actually if you happen to seen nearly 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And if you happen to take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, actually there are 10 instances extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the capabilities of those micro organism that actually modifications how these micro organism behave by way of what capabilities they’re performing.
So once more, what’s actually fascinating is by taking a look at what organisms are there, won’t ever inform you what’s going on in your physique. In truth, their capabilities are what makes the distinction. Which means what they’re producing can…is de facto the one factor that issues what these intestine microbes are producing, not who they’re. And I feel, Katie, you in all probability know that a whole lot of the individuals like Akkermansia muciniphila. A number of the corporations are promoting them as a probiotic with out realizing that Akkermansia will be good for some individuals and actually it’s the primary cause for inflicting a number of sclerosis, and it has additionally been instantly linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and may do one thing actually unhealthy in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different individual’s physique. The identical organism or identical probiotic will be good for somebody and could possibly be dangerous for one more individual. And that’s the most important studying we have now had within the final six years.
Katie: Yeah, I really like that you simply introduced up the fecal microbiota switch as effectively. I’ve seen among the science on this and… you already know, caveat, this isn’t one thing to try at residence however it’s fairly superb what they’re engaging in in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you may accomplish with out having to go to that excessive if you already know what you’re working with. And for the final two years, I’ve been saying, you already know, early on in well being and wellness, I’d discover out info, learn research and be so excited and write about it, and I’ve realized increasingly more over the past 15 years every part is so customized and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “, I can inform you what I did however it’s not gonna work the identical for you. It may be an concept with the place to begin however it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”
Which is why I really like now increasingly more entry to those at-home testing whether or not it’s issues like Viome, even now blood testing out there at residence, genetic testing simply so we are able to have extra info and entry. And I’ve stated so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that permit us be simpler at that may actually, actually make a distinction. So, let’s speak a bit of bit extra in regards to the personalization facet of this as a result of I additionally am curious…you already know, I do know you stated every part is so totally different. What’s good for one individual may be not for one more. Are there any issues which can be type of universally unhealthy that you simply’re discovering in Viome? Like, I’d put perhaps processed vegetable oils on the don’t cross checklist, however I’m curious what you’re seeing within the information.
Naveen: Yeah. So to start with, it’s actually fascinating. I feel you phrased it appropriately. There isn’t any such factor as common wholesome meals. And which means there isn’t a such factor that’s good for everybody. Which means the identical meals will be good for you or unhealthy for somebody. Nonetheless, there are some common unhealthy issues that you would be able to know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a kind of unhealthy issues. There isn’t any one who says, “The sugar is sweet for me, proper.” In order that’s truly having a fried, you already know, fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming a whole lot of sugar, it’s simply unhealthy for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I feel a whole lot of the people who find themselves listening to it, I need individuals to know the distinction between a DNA which is static. So when individuals do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t inform you what is definitely occurring in your physique. Which means…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I feel to me lots of people get very confused about what DNA is.
So, each a part of our physique is an identical DNA. Which means you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Identical DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can grow to be eye, identical DNA can grow to be nail, identical DNA can grow to be pores and skin, identical DNA can grow to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s referred to as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each doable factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and inform you…some information to share with you in direction of the top. As soon as we perceive all that’s occurring, we’re capable of then inform you, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is just too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so you must lower it down, proper.”
We are able to inform you that…lots of people will inform you go take vitamin B3. However vitamin B3’s truly not good for you when you may have excessive uric acid manufacturing. So don’t take vitamin B3 when you’ve got excessive uric acid manufacturing. Equally, everybody will inform you, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t wish to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume by some means taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some individuals it might do this, however for others it truly will hurt you when you may have excessive mobile senescence, or when you may have excessive inflammatory exercise. You don’t wish to be taking extra NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.
So, the thought actually is that you need to be taught what is occurring earlier than you deal with your physique like a black field. And I feel you’ve stated it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is occurring in our physique as a result of our major care physician…I don’t learn about you, Katie. After I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the sick, I’ll provide the capsule.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or if you happen to had any kind of an autoimmune illness, the very first thing they inform you is simply take the immune suppression medicine and suppress the symptom. Not fear about what’s inflicting it, and that could be a basic downside that our healthcare system has is that our medical industrial advanced, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to alter that. In my world of the longer term, Katie, we consider that…I feel identical to you simply stated, the way forward for healthcare goes to be delivered at residence, not on the hospitals.
And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I feel COVID has been one of many…I’d say if you happen to look again at COVID 10 years from now, will probably be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I feel so many good silver linings and educating moments in COVID and other people spent extra time at residence and with their households cooking dinner at residence. There have been a whole lot of nice outcomes, as exhausting because it was for many individuals. I feel we are able to concentrate on these positives. And I really like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a bit of bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some huge advances since then. So, discuss type of the snapshot of what Viome is testing after which how individuals are making modifications based mostly on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good however it didn’t inform us how these intestine modifications have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID truly, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now take a look at each your intestine well being and your human host and capable of now inform you what’s your organic age. And that tells you not solely, you already know, how effectively or how poorly your physique is getting old in comparison with your chronological age.
So, to offer you an concept, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the degree after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than actually I had after I was 50. And that merely tells you what your organic age is. Then we offer you immune well being. Which means how effectively are you protected towards if you happen to have been to catch flu or chilly or any kind of pathogen, how effectively your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you the way effectively your cells are capable of endure the issues which can be occurring within the human physique. Mitochondrial well being, that’s your vitality manufacturing unit. How effectively the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you are feeling fatigued, you are feeling drained. We offer you clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product referred to as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from high of your tube, your saliva, your stool and blood, all three on the identical time. And by taking a look at that, we’re additionally gonna have the ability to present you some extra insights akin to your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna have the ability to present you your oral well being akin to your gum well being, your tooth well being and all of the gum, you already know…leaky gum as an alternative of simply leaky intestine. We’ll have the ability to present you the way effectively your boundaries of your gums are performing in order that microbes usually are not going into your blood.
And different factor we do now which we didn’t do till a couple of yr in the past is once you do a take a look at, not solely you get your deep perception what’s occurring in your physique and never simply inform you listed here are the meals which can be good for you and right here is why. Listed here are the meals you must keep away from and why. We used to inform you listed here are the dietary supplements you must take. Now we transcend that, Katie. We’re capable of inform you you solely want 22 milligram of berberine daily. You want 17 milligram of elderberry daily. You want 79 milligram amylase daily. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique modifications, we modify your dietary supplements on the identical time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of modify your…as your physique is altering, we adapt the vitamin that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and we have now not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll have the ability to spit in a tube and with 95% specificity and 90% sensitivity, we’ll have the ability to inform you when you’ve got any oral most cancers or throat most cancers. After which we’ll have the ability to truly join you with a physician to have the ability to do one thing about it. So, in case you are above…over 50 years outdated or have any historical past of smoking, vaping, chewing tobacco, you’ll have the ability to truly at residence do a take a look at and truly know that you simply’re not at a danger of creating a most cancers proper now. Otherwise you’re creating a most cancers proper now.
Katie: Yeah. That is so innovative and I feel simply to spotlight what you stated, that is actually fascinating information of mainly machine studying and AI and this adaptive know-how. And since you’ve now examined 1000’s and 1000’s, in all probability a whole bunch of 1000’s of individuals, then the algorithm has entry to all this info so it will probably proceed to get increasingly more specialised and direct with the suggestions and be taught your individual physique over time. So, you’re getting this type of ongoing, correct image which I feel is so fascinating.
Naveen: Yeah. So, Katie, we have now analyzed over 350,000 samples already. And that has given us this…you already know, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that we have now analyzed they usually contribute to the ecosystem, and our AI and machine studying is consistently getting higher. And for each single one who joins profit themselves and advantages the humanity on the identical time as a result of now the extra we be taught, the higher suggestions we are able to make for everybody. So, earlier than we simply solely may take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor will likely be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get increasingly more exact as we be taught increasingly more in regards to the human physique. And our actual hope is, you already know, in my lifetime we’ll have the ability to perceive what causes the onset of a continual illness and what causes them to progress and to have the ability to forestall them from occurring within the first place, to diagnose them early once they truly do occur, and to provide you with a treatment for these illnesses. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the final word objective of our life.
Katie: And I really like that you simply introduced up the interplay of all of the totally different microbiomes throughout the physique as effectively and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the identical time. And it is because we have now an oral microbiome. And if it will get out of steadiness in a single path or the opposite, you’re gonna find yourself with these issues. However the reply is just not sterilizing your mouth and killing all micro organism identical to we wouldn’t wish to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Identical factor with the intestine. And such as you stated, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to speak along with her about that.
However I feel, like we talked about at first, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra type of intricate information we are able to get to make enhancements over time and naturally there can be a most cancers connection right here. , I’ve heard it stated that most cancers is a metabolic illness in some half. And this can be a approach of…as a result of even inside a person, if you happen to’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in test. We have to get blood strain in test. We have to get weight problems measures in test.” However the best way to try this’s gonna be totally different for each single individual.
Naveen: I feel it’s a metabolic and inflammatory illness. So, I imply, it’s precipitated…continual irritation is a root explanation for continual illnesses. Nonetheless, what causes the irritation in our physique is totally different for every particular person. So regardless that it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, you already know…has this firm referred to as Evvy, E-V-V-Y, which appears on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to do this as a result of that’s actually…goes to be…you already know, plenty of ladies endure by most of the illnesses that we as males would by no means perceive. And that to some extent is, you already know, largely reproductive organ and most of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm beginning, within the well being of the child and all of the issues that you simply talked about because the child goes by the beginning canal. All of the issues that come out actually are contributory from the vaginal microbiome. So, my excessive suggestion…once more, I’m biased. I feel each girl needs to be doing the Evvy take a look at, proper.
Now, coming again to the stuff you talked about that, you already know, human well being is advanced however as soon as we perceive biochemical degree what’s going on, that’s the rationale as an alternative of taking a look at organisms and as an alternative of taking a look at DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Trying on the complete physique. And I feel, Katie, I wanna level out that the merchandise that you simply construct for oral well being are among the greatest merchandise as a result of, to me, what’s the greatest gamechanger is individuals thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. Whenever you kill the ecosystem in your mouth, it truly destroys the entire digestive tract. And I wanna simply emphasize, you already know, to individuals when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too huge to go down our esophagus, proper. It was truly was once you chew your meals, you’re permitting the oral microbiome in your saliva to really predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the primary factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now take in the vitamins which can be already predigested. So, when you’re…so two issues that you must take into consideration right here. And one is when you’re burdened and you’re consuming your meals, it doesn’t get correctly digested and right here is why. When you find yourself burdened, you’re in a battle or flight response. And the primary factor that occurs once you’re in battle or flight response is your digestive system shuts down. Keep in mind why it was designed. Whenever you’re working away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And if you happen to turned lunch for another person, it didn’t matter. And if you happen to survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you may digest your meals.
Whenever you come from work and you’re burdened, what will we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you wish to convey your physique from sympathetic mode into parasympathetic mode. Eliminate battle or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to really predigest your meals. And these are easy strategies we realized within the historical tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you could not know that my mother and pa and our faith, they don’t eat after sundown. And I at all times marvel why would that be. And it seems as a result of that you must have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, actually telling that, you already know…and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.
And I wanna come again to the oral merchandise. I feel individuals must be actually fascinated with oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you already know, probiotics. And the merchandise, among the merchandise that you’ve got, Katie, are designed to boost your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I feel everybody who’s listening to it to start out listen as a result of that’s the primary. Your mouth truly is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I feel very multifaceted however begin with the mouth is so necessary. And I really like a few the stuff you simply talked about about why we don’t digest meals if we’re burdened and we all know, after all, that Individuals reside in a continual state of stress typically. And one factor I’ve grow to be keen on…you already know, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you may merely do respiration workouts. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a non secular perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice after I time restricted eat and for a very long time I’d wait and never eat until midday after which eat later within the day. And I seen after I shifted that to consuming and stopping by sundown, I really feel so a lot better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you will be therapeutic and your physique can get into autophagy and you’ll allocate assets to all of the pure processes the physique has inbuilt to maintain us wholesome.
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And I additionally wanna piggyback on what you stated about the identical cause we don’t wanna kill our oral microbiome is similar cause we don’t wanna kill our intestine micro organism as effectively however I nonetheless see individuals type of hopping on the bandwagon of those actually harsh cleanses or after all individuals generally take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh influence on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine problem associated to essentially type of killing a few of these good micro organism. Clearly, Viome helps with this however type of, like, what will be executed? How can we assist repair it?
Naveen: So, very first thing is, you already know, earlier than you go begin taking a whole lot of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And then you definately begin to take a look at what you…you already know, we inform you what are the meals you must eat. And once more, taking a whole lot of the fermented meals particularly once you’re making an attempt to repopulate or rebootilate your intestine microbiome, actually the issues needs to be diversification. So as an alternative of simply taking one kind of probiotics, try to be taking kombucha, the kimchi, the…you already know, all of the fermented meals you may presumably get your palms on. So, whether or not it’s a yogurt or, you already know, no less than oat milk yogurt if you happen to can. I imply, I’m a giant fan that I feel dairy…actually for lots of the individuals, dairy is the massive downside. Now I’m not saying it’s for everybody however a whole lot of the individuals, dairy could possibly be a giant downside. And the mammalian merchandise truly could possibly be a giant downside for some individuals and never for others.
So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is sweet for you. There are lots of people who can eat pink meat for all of their life and reside to be 100, and the rationale for that’s pink meat incorporates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the pink meat that causes the center illness. It’s the byproduct of how the pink meat is digested in some those that produce TMA. So, in case your TMA manufacturing is low, you must eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and complete class of meals.
One other factor that we realized…we printed a paper having analyzed over 100,000 individuals at the moment on getting old. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you already know, keto weight loss program or paleo weight loss program have been the worst offender of their organic age. The individuals who have been on keto weight loss program actually have been three to 5 years older than their chronological age and the identical is true for paleo weight loss program. It seems that people who find themselves on balanced weight loss program, which means they have been consuming their carbs however not lots however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats they usually have been consuming the protein, they have been way more balanced, have been truly higher off biologically than chopping out the entire nutrient group utterly.
Katie: That is smart, that we want the variability. And I’ve realized increasingly more as effectively that I feel the simplistic model all of us realized, hopefully realized in class was about simply type of energy in, energy out. And I’ve heard it stated, you already know, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and necessary than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re continually doing analysis right here, and such as you stated, your objective is to sort out continual illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly more exact for each particular person since we make it for every particular person. We’re, you already know, making an attempt to do extra exams now and our objective is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can’t see within the blood as a result of they’re produced elsewhere. So, can we measure issues, you already know, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict when you’ve got a leaky intestine by taking a look at LBP, by taking a look at CRP which truly is finished within the liver? So, we’re going to have the ability to truly measure extra issues along with simply those that we’re measuring, and the extra info we are able to be taught, the higher suggestions we make. So, our hope is to proceed to launch these exams that give us higher and higher insights and which means we are able to make increasingly more exact suggestion for every particular person.
Final objective actually is to know…as you say, the human physique is a chemistry lab. We have now mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to know that the gene expression tells you what biochemistry is occurring within the physique. And that’s a cause…and actually, Viome is the one firm that does take a look at the gene expression as a result of there isn’t a different firm that has this know-how. And I feel individuals who have listened to your earlier podcast, we talked about, this specific know-how got here out of Los Alamos Nationwide Lab the place they’d the laboratory for biodefense challenge. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ value of assets to develop this know-how. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this know-how to assist the humanity get higher. And if our mission was merely to generate income, we might not have been capable of license this know-how, proper.
So, the very fact at present we’re merely targeted on making each single individual be higher. , our mission on day one was what if we may perceive the human biology at a molecular degree so we are able to forestall, diagnose early and treatment these continual illnesses together with most cancers and getting old? And I feel a whole lot of the individuals who have heard you and I speak up to now, you already know that I misplaced my dad to most cancers and that was one of many greatest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have doubtlessly saved my dad. And, you already know, having watched him undergo that ache or struggling by most cancers I spotted that regardless that I couldn’t save him, I may dedicate my life to saving everybody else. And that will likely be my approach of letting him know that, you already know, I’m so pleased with what he…how he raised us as a baby and giving us every part we have now so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.
And my hope actually is that in our lifetime we’ll completely eradicate most cancers from the human physique. And if I have been to make a prediction at present, I’ll inform you inside a decade I feel we’ll do away with most cancers from the human physique.
Katie: That’s a giant declare and I hope we’re on monitor for that as effectively. I’ve misplaced two prolonged relations within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the continual stress of the final couple of years is just not serving to that downside. So, I’m grateful that there are assets such as you, and I’ve executed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be certain…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. You’ll find the low cost code and the hyperlink on to it there. And to ensure I respect your time, there’s a pair final questions I’d like to ask you. The primary being if there’s a ebook or a lot of books which have profoundly influenced your life. And if that’s the case, what they’re and why?
Naveen: Yeah, so the ebook that actually influenced me…there’s a ebook by Clayton Christensen, you already know. I really like the person and I noticed him earlier than he died. The ebook he wrote, “How Will You Measure Your Life?” And to me it was such a profound ebook which tells you that you need to be 100% sincere. You can’t be 99% sincere as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll at all times be one more reason to make an exception. And so, you need to focus your self to by no means, ever compromise in your ideas that you simply stand for. And that was simply completely a fabulous ebook I learn.
, the ebook that additionally…I imply, clearly I wrote a ebook referred to as “Moonshots” that’s actually about making a mindset of abundance quite than a mindset of shortage. And the basic perception that I’ve is that there’s nothing that people usually are not able to doing if we truly get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to resolve whether or not they can or they will’t. That when you consider one thing is unimaginable, it turns into unimaginable for you and nobody else. And so, you’re utterly in management. The one factor you may’t do is what you may’t think about. All the things else is feasible.
Katie: I really like that. I do know you and I each increase our children with that mindset and yours are older and doing superb issues out on the planet already and mine are at first phases of that. And lastly, what parting recommendation would you want to go away with the viewers at present? May very well be associated to one thing we’ve talked about or totally unrelated.
Naveen: I’d say dream so huge that folks assume you’re loopy. Which means by no means let somebody inform you that you would be able to’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self is just not about being self-conceited. Loving your self is about not on the lookout for another person’s approval to do the issues that imply lots to you. Observe your coronary heart, comply with your intestine, hearken to your intestine and comply with what it tells you. Discover a objective in life. When you discover a objective in life, you’ll by no means ever assume it’s work. I stand up daily at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, if you happen to’re not leaping out of the mattress, you must give up what you’re doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You bounce out of the mattress with pleasure wanting to unravel that downside.
And, Katie, I simply wish to reiterate, I met your youngsters and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your youngsters are going to really transfer this humanity ahead. You might be elevating these youngsters with the mindset that every part they wish to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a whole lot of instances. Like, after we increase our youngsters, we inform them, “Our love for you is unconditional however our approval is just not.” And what which means is just is that we’ll at all times love you, we’ll at all times be there for you, however I’m not gonna inform you I’m pleased with you until you do issues that make us pleased with you. And that’s actually the factor about telling the youngsters that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It will likely be measured by what number of lives they enhance. And the humility is an indication of success as a result of if you happen to nonetheless have iota of vanity left in you, which means you’re nonetheless making an attempt to show one thing to your self or another person. And humility tells you not have to try this, proper. And that could be a true signal of success. And all I can say is I’m so pleased with each certainly one of your youngsters, Katie. And I can’t anticipate them to develop up and truly do issues that can make our youngsters’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over truly parenting earlier than we ever talked about well being. And we share that similarity. I inform my youngsters daily, “I really like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you may ever do that might take away from my love.” However you’re proper. Additionally, I need that, like, their delight to return from within, like…and I inform them typically, “You have to really feel actually pleased with how exhausting you labored and you should…” As a result of I need them to have that inside them and that self-love.
And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening at present of mothers, as a result of I feel mothers have such an incredible distinctive capability to essentially shift the way forward for humanity by how we guardian our children and by serving to kind these future leaders. And for individuals who aren’t already conversant in you, I’d encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your youngsters on their life journeys and your spouse in her personal proper is unimaginable as effectively. So very grateful in your complete household and for all that every one of you’re doing on the planet and in your time at present. I understand how busy you’re and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s at all times an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.
Katie: And thanks, as at all times, to all of you for listening and sharing your most respected assets, your time, your vitality, and your consideration with us at present. We’re each so grateful that you simply did. And I hope that you’ll be a part of me once more on the subsequent episode of the “Wellness Mama” podcast.
In case you’re having fun with these interviews, would you please take two minutes to go away a score or evaluation on iTunes for me? Doing this helps extra individuals to search out the podcast, which suggests much more mothers and households may gain advantage from the knowledge. I actually respect your time, and thanks as at all times for listening.
